Buscar

Acrocomia crispa fruits lipid extract prevents LPS-induced acute lung injury in mice

terça-feira, setembro 24, 2019

A) Negative control. Normal appearance of alveolar walls without signs of inflammation; B) Positive control showing severe neutrophil infiltration and alveolar thickening;
Authors: Licet Mena, Roxana Sierra, Maikel Valle, Vivian Molina, Sandra Rodriguez, Nelson Merino, Zullyt Zamora, Victor González & Jose Alberto Medina

Abstract: The aim of this study was to evaluate the effects of single oral doses of D-005 (a lipid extract obtained from the fruit oil of Acrocomia crispa) on LPS-induced acute lung injury (ALI) in mice. D-005 batch composition was: lauric (35.8%), oleic (28.4%), myristic (14.2%), palmitic (8.9%), stearic (3.3%), capric (1.9%), caprylic (1.2%), and palmitoleic (0.05%) acids, for a total content of fatty acids of 93.7%. 

D-005 (200 mg/kg) significantly reduced lung edema (LE) (≈ 28% inhibition) and Lung Weight/Body Weight ratio (LW/BW) (75.8% inhibition). D-005 (25, 50, 100 and 200 mg/kg) produced a significant reduction of Histological score (59.9, 56.1, 53.5 and 73.3% inhibition, respectively). 

Dexamethasone, as the reference drug, was effective in this experimental model. In conclusion, pretreatment with single oral doses of D-005 significantly prevented the LPS-induced ALI in mice.

To read the full article, click here.

Page: Research Gate

Veja também:

0 comentários

Agradecemos seu comentário! Volte sempre :)

Categorias

Acrocomia aculeata (2) Alimentos (217) animal nutition (1) Aspectos Gerais (172) Aviação (24) Aviation market (13) Biocombustíveis (166) Biodiesel (68) Bioeconomia (15) Bioeletricidade (2) Biofertilizantes (1) Biofuels (82) Biomass (7) Biomassa (49) Biopolímeros (3) Bioquerosene (18) Biotechnology (21) Biotecnologia (2) Brazil (19) Cerrado (1) Ciência e Tecnologia (172) Clima e ambiente (180) climate changed (20) Cogeração de energia (9) COP24 (75) COP25 (13) Cosméticos (19) Crédito de Carbono (25) Cultivo (96) eco-friendly (2) Economia Internacional (60) Economia Verde (154) Economy (25) Ecosystem (1) Efeito estufa (4) Energia (26) Energia Renovável (149) event (6) Eventos (70) Extrativismo (19) Farelos (27) farm (1) Fibras (8) Floresta plantada (62) Food (40) food security (1) Fuels (16) Global warming (77) Green Economy (111) health (21) Industry 4.0 (1) IPCC (13) livestock (4) Low-Carbon (39) Lubrificantes e Óleos (17) Macaúba (491) Manejo e Conservação (37) Meio Ambiente (78) Melhoramento e Diversidade Genética (52) Mercado (3830) Mercado florestal (42) Nutrição animal (15) nutrition (9) Oil (42) Óleos (209) other (1) Paris Agreement (56) Pecuária (59) Pegada de Carbono (40) pirólise (1) Plant Based (6) Política (49) Produtos (140) proteína vegetal (21) Recuperação de área Degradada (22) renewable energy (10) Research and Development (7) SAF (1) Saúde e Bem-Estar (72) science and technology (25) Segurança Alimentar (34) Soil (7) Solos (8) Sustainability (34) Sustainable Energy (52) Sustentabilidade (284) Vídeo (193) World Economy (62)

Total de visualizações de página